Article
Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias.
Blood - 15 Oct 1994
Ogawa S, Hirano N, Sato N, Takahashi T, Hangaishi A, Tanaka K, Kurokawa M, Tanaka T, Mitani K, Yazaki Y
Abstract excerpt
Recently, it has been shown that the homozygous deletion of the cyclin-dependent kinase-4 inhibitor (CDK4I;p16) gene, which is mapped to chromosome 9p21, is frequently observed in a wide spectrum of human cancers, including leukemias. Therefore, the CDK4I gene is thought to be a putative tumor-su...
Topics
- Adult
- Alleles
- Base Sequence
- Blotting, Southern
- Carrier Proteins
- Child, Preschool
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Female
- Gene Deletion
- Homozygote
- Humans
- Leukemia
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Acute
- Male