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Article

Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias.

Blood - 15 Oct 1994

Ogawa S, Hirano N, Sato N, Takahashi T, Hangaishi A, Tanaka K, Kurokawa M, Tanaka T, Mitani K, Yazaki Y

Abstract excerpt

Recently, it has been shown that the homozygous deletion of the cyclin-dependent kinase-4 inhibitor (CDK4I;p16) gene, which is mapped to chromosome 9p21, is frequently observed in a wide spectrum of human cancers, including leukemias. Therefore, the CDK4I gene is thought to be a putative tumor-suppressor gene. We report here that both alleles of the CDK4I gene were completely or partially deleted in human...

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PMID: 7919362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias.PMID 7919362Read ↗

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