Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of hemizygous deletions in genomic DNA from leukaemia specimens for the diagnosis of patients.

Leukemia research - 1 Feb 2005

Kees Ursula R, Terry Philippa A, Ford Jette, Everett Janet, Murch Ashleigh, de Klerk Nick, Baker David L

Abstract excerpt

Hemizygous deletions in genomic DNA appear to play an important role in tumorigenesis. The loss or inactivation of tumour suppressor genes (TSGs) is of critical importance in most malignancies, and has been shown to affect response to therapy. Here, we report a quantitative real-time polymerase chain reaction (qPCR) designed to detect two TSGs at the CDKN2A locus, p16(INK4A) and p14(ARF) that allows the detection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to In Situ Hybridization, Fluorescence

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Tumor Suppressor Protein p14ARF

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 15607365
DOI: 10.1016/j.leukres.2004.05.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Detection of hemizygous deletions in genomic DNA from leukaemia specimens for the diagnosis of patients.PMID 15607365Read ↗

Hemizygous p16(INK4A) deletion in pediatric acute lymphoblastic leukemia predicts independent risk of relapse.Semantic proximity Read ↗

Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic featuresSemantic proximity Read ↗

Deletion of one copy of the p16INK4A tumor suppressor gene is implicated as a predisposing factor in pediatric leukemia.Semantic proximity Read ↗

Inverse correlation between Ink4-locus deletions and ICM-DNA hyperdiploidy in childhood acute lymphoblastic leukaemia, relation to clinical characteristics and outcome.Semantic proximity Read ↗

Detecting homozygous deletions in the CDKN2A(p16(INK4a))/ARF(p14(ARF)) gene in urinary bladder cancer using real-time quantitative PCR.Semantic proximity Read ↗

Analysis of p16 gene mutations and deletions in childhood acute lymphoblastic leukemias.Semantic proximity Read ↗

Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemiaSemantic proximity Read ↗

Mutation of p16, p21 or cyclin dependent kinase 4 is rare in acute lymphoblastic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.