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Article

Acquisition of p16INK4Aandp15INK4BGene Abnormalities Between Initial Diagnosis and Relapse in Children With Acute Lymphoblastic Leukemia

1 Apr 1999

Abstract excerpt

Although numerous somatic mutations that contribute to the pathogenesis of childhood acute lymphoblastic leukemia (ALL) have been identified, no specific cytogenetic or molecular abnormalities are known to be consistently associated with relapse. The p16(INK4A) (p16), which encodes for both p16(INK4A) and p19(ARF) proteins, and p15(INK4B) (p15) genes are inactivated by homozygous deletion and/or p15 promoter...

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PMID: 10090949
DOI: 10.1182/blood.v93.7.2380

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