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Article

Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.

International journal of cancer - 26 Sept 1997

Hegi M E, zur Hausen A, Rüedi D, Malin G, Kleihues P

Abstract excerpt

The p16INK4a gene product acts as a negative regulator of the cell cycle by binding to cyclin-dependent kinases (CDKs) 4 and 6, thereby inhibiting the formation of an active CDK/cyclin D complex. Deletion of the p16 locus has been observed in tumor cell lines and, less frequently, in primary human neoplasms. We analyzed 31 glioblastomas and identified 6 cases with hemizygous and 6 with homozygous deletions of the...

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Identifiers

PMID: 9334810
DOI: 10.1002/(sici)1097-0215(19970926)73:1<57::aid-ijc10>3.0.co;2-2

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.PMID 9334810Read ↗

p16 Immunohistochemical Expression as a Surrogate Assessment of CDKN2A Alteration in Gliomas Leading to Prognostic SignificancesSemantic proximity Read ↗

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CDKN2A deletion in pediatric versus adult glioblastomas and predictive value of p16 immunohistochemistrySemantic proximity Read ↗

Loss of P16INK4 expression is frequent in high grade gliomas.Semantic proximity Read ↗

p14ARF deletion and methylation in genetic pathways to glioblastomas.Semantic proximity Read ↗

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.Semantic proximity Read ↗

Determination of p53 Mutations, EGFR Overexpression, and Loss of p16 Expression in Pediatric GlioblastomasSemantic proximity Read ↗

Functional analysis of wild-type and malignant glioma derived CDKN2Abeta alleles: evidence for an RB-independent growth suppressive pathway.Semantic proximity Read ↗

Mutations of the p16 gene in gliomas.Semantic proximity Read ↗

Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.Semantic proximity Read ↗

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.Semantic proximity Read ↗

Retinoblastoma gene deletions in human glioblastomas.Semantic proximity Read ↗

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