Article
Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.
International journal of cancer - 26 Sept 1997
Hegi M E, zur Hausen A, Rüedi D, Malin G, Kleihues P
Abstract excerpt
The p16INK4a gene product acts as a negative regulator of the cell cycle by binding to cyclin-dependent kinases (CDKs) 4 and 6, thereby inhibiting the formation of an active CDK/cyclin D complex. Deletion of the p16 locus has been observed in tumor cell lines and, less frequently, in primary huma...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cyclin D1
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Methylation
- ErbB Receptors
- Female
- Gene Deletion
- Glioblastoma
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- RNA, Messenger