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Article

Allelic expression imbalance of CDKN2A variants in childhood acute lymphoblastic leukemia.

Cellular oncology (Dordrecht, Netherlands) - 1 Jun 2025

Tang Zhexuan, Pei Kunlin, Xu Haoyu, Zheng Yongzhi, Zhuang Shuquan, Weng Kaizhi, He Yingyi, Wu Jing, Zhang Hui

Abstract excerpt

INTRODUCTION: Germline CDKN2A variant predisposes to childhood acute lymphoblastic leukemia (ALL) through allelic expression imbalance (AEI). It is unknown, therefore, how these germline variations work and whether they all confer B-ALL susceptibility through AEI. METHODS AND RESULTS: Using allele-specific Taqman PCR assays, we demonstrated that preferentially expressed of those functional inherited coding...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40035982
DOI: 10.1007/s13402-025-01049-6
PMCID: PMC12119667

Genes

CDKN2A
ABL1
BCR
CRLF2
CDK4
F3
PRRC2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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