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Article

[Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis].

Journal de la Societe de biologie - 1 Jan 2004

Côté Francine, Fligny Cécile, Mallet Jacques, Vodjdani Guilan

Abstract excerpt

Serotonin (5-HT) controls a wide range of biological functions. In the brain, its implication as a neurotransmitter and in the control of behavioral traits has been largely documented. At the periphery, its modulatory role in physiological processes, such as the cardiovascular function, is still poorly understood. The rate limiting enzyme of 5-HT synthesis, tryptophan hydroxylase (TPH), is encoded by two genes:...

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Source

Identifiers

PMID: 15146950

Genes

TPH1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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[Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis].PMID 15146950Read ↗

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.Semantic proximity Read ↗

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TPH2 knockout male rats are aggressive, show less anxiety, and exhibit an altered oxytocin systemSemantic proximity Read ↗

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development.Semantic proximity Read ↗

Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function.Semantic proximity Read ↗

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