Article
Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function.
Circulation - 19 Jun 2001
Nebigil C G, Hickel P, Messaddeq N, Vonesch J L, Douchet M P, Monassier L, György K, Matz R, Andriantsitohaina R, Manivet P, Launay J M, Maroteaux L
Abstract excerpt
BACKGROUND: Identification of factors regulating myocardial structure and function is important to understand the pathogenesis of heart disease. Because little is known about the molecular mechanism of cardiac functions triggered by serotonin, the link between downstream signaling circuitry of its receptors and the heart physiology is of widespread interest. None of the serotonin receptor (5-HT(1A), 5-HT(1B), or...
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