Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2011

Amireault Pascal, Hatia Sarah, Bayard Elisa, Bernex Florence, Collet Corinne, Callebert Jacques, Launay Jean-Marie, Hermine Olivier, Schneider Elke, Mallet Jacques, Dy Michel, Côté Francine

Abstract excerpt

Serotonin (5-HT) has long been recognized as a neurotransmitter in the central nervous system, where it modulates a variety of behavioral functions. Availability of 5-HT depends on the expression of the enzyme tryptophan hydroxylase (TPH), and the recent discovery of a dual system for 5-HT synthesis in the brain (TPH2) and periphery (TPH1) has renewed interest in studying the potential functions played by 5-HT in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Dietary Supplements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythroid Precursor Cells

Share to Erythropoiesis

Share to Receptors, Serotonin

Share to Serotonin

Share to Serotonin Receptor Agonists

Share to Tryptophan Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 21788492
DOI: 10.1073/pnas.1103964108
PMCID: PMC3156216

Genes

TPH1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice.PMID 21788492Read ↗

Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral SerotoninSemantic proximity Read ↗

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read ↗

Genetic Models of Serotonin (5‐HT) Depletion: What do They Tell Us About the Developmental Role of 5‐HT?Semantic proximity Read ↗

Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin.Semantic proximity Read ↗

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.Semantic proximity Read ↗

[Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis].Semantic proximity Read ↗

Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.Semantic proximity Read ↗

Maternal serotonin is crucial for murine embryonic development.Semantic proximity Read ↗

A tryptophan hydroxlyase 1 reporter that directs Cre recombinase extinguishable placental alkaline phosphatase expression in serotonergic (5-HT) neurons and peripheral tissues.Semantic proximity Read ↗

Tryptophan hydroxylase-2 controls brain serotonin synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.