Article
Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development.
Nature - 13 Apr 1995
Zhou Q Y, Quaife C J, Palmiter R D
Abstract excerpt
Tyrosine hydroxylase catalyses the initial, rate-limiting step in the catecholamine biosynthetic pathway. Catecholamines, which include dopamine, noradrenaline, and adrenaline, are important neurotransmitters and hormones that regulate visceral functions, motor coordination and arousal in adults....
Topics
- Alleles
- Animals
- Base Sequence
- Cardiovascular Diseases
- Catecholamines
- Cell Line
- DNA
- Embryonic and Fetal Development
- Female
- Levodopa
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Molecular Sequence Data
- Mutagenesis
- Pregnancy
- Tyrosine 3-Monooxygenase