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Article

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development.

Nature - 13 Apr 1995

Zhou Q Y, Quaife C J, Palmiter R D

Abstract excerpt

Tyrosine hydroxylase catalyses the initial, rate-limiting step in the catecholamine biosynthetic pathway. Catecholamines, which include dopamine, noradrenaline, and adrenaline, are important neurotransmitters and hormones that regulate visceral functions, motor coordination and arousal in adults. The gene encoding tyrosine hydroxylase becomes transcriptionally active in developing neuroblasts during mid-gestation...

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PMID: 7715703
DOI: 10.1038/374640a0

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