Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice.

Molecular and cellular biology - 1 Jul 2002

Cogliati Tiziana, Good Deborah J, Haigney Mark, Delgado-Romero Petra, Eckhaus Michael A, Koch Walter J, Kirsch Ilan R

Abstract excerpt

Nhlh1 is a basic helix-loop-helix transcription factor whose expression is restricted to the nervous system and which may play a role in neuronal differentiation. To directly study Nhlh1 function, we generated null mice. Homozygous mutant mice were predisposed to premature, adult-onset, unexpected death. Electrocardiograms revealed decreased total heart rate variability, stress-induced arrhythmia, and impaired...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmias, Cardiac
Share to Autonomic Nervous System Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Basic Helix-Loop-Helix Transcription Factors

Share to Bradycardia

Share to Brain Stem

Share to Electrocardiography

Share to Heart Conduction System

Share to Heart Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 12077327
DOI: 10.1128/MCB.22.14.4977-4983.2002
PMCID: PMC139775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice.PMID 12077327Read ↗

Human phenotypes and animal knockout models of genetic autonomic disorders.Semantic proximity Read ↗

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.Semantic proximity Read ↗

Nhlh2Semantic proximity Read ↗

Abnormal heart rate regulation in murine hearts with familial hypertrophic cardiomyopathy-related cardiac troponin T mutations.Semantic proximity Read ↗

Phenotypic screening for heart rate variability in the mouse.Semantic proximity Read ↗

[Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis].Semantic proximity Read ↗

Modified autonomic regulation in mice mutated in the β4 subunit of the lh/lh calcium channel.Semantic proximity Read ↗

Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not.Semantic proximity Read ↗

Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability.Semantic proximity Read ↗

Firing activity of locus coeruleus noradrenergic neurons decreases in necdin-deficient mice, an animal model of Prader–Willi syndromeSemantic proximity Read ↗

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease.Semantic proximity Read ↗

Noradrenergic neuronal development is impaired by mutation of the proneural HASH-1 gene in congenital central hypoventilation syndrome (Ondine's curse).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.