Article
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003
Côté Francine, Thévenot Etienne, Fligny Cécile, Fromes Yves, Darmon Michèle, Ripoche Marie-Anne, Bayard Elisa, Hanoun Naima, Saurini Francoise, Lechat Philippe, Dandolo Luisa, Hamon Michel, Mallet Jacques, Vodjdani Guilan
Abstract excerpt
Serotonin (5-HT) controls a wide range of biological functions. In the brain, its implication as a neurotransmitter and in the control of behavioral traits has been largely documented. At the periphery, its modulatory role in physiological processes, such as the cardiovascular function, is still poorly understood. The rate-limiting enzyme of 5-HT synthesis, tryptophan hydroxylase (TPH), is encoded by two genes,...
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