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Article

Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 May 2016

Kaplan Kara, Echert Ashley E, Massat Ben, Puissant Madeleine M, Palygin Oleg, Geurts Aron M, Hodges Matthew R

Abstract excerpt

Genetic deletion of brain serotonin (5-HT) neurons in mice leads to ventilatory deficits and increased neonatal mortality during development. However, it is unclear if the loss of the 5-HT neurons or the loss of the neurochemical 5-HT led to the observed physiologic deficits. Herein, we generated a mutant rat model with constitutive central nervous system (CNS) 5-HT depletion by mutation of the tryptophan...

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Identifiers

PMID: 26869713
DOI: 10.1152/japplphysiol.01015.2015
PMCID: PMC4855209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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