Article
Breast carcinoma cells promote the differentiation of CD34+ progenitors towards 2 different subpopulations of dendritic cells with CD1a(high)CD86(-)Langerin- and CD1a(+)CD86(+)Langerin+ phenotypes.
International journal of cancer - 10 Jul 2004
Thomachot Marie Cécile, Bendriss-Vermare Nathalie, Massacrier Catherine, Biota Cathy, Treilleux Isabelle, Goddard Sophie, Caux Christophe, Bachelot Thomas, Blay Jean Yves, Menetrier-Caux Christine
Abstract excerpt
Primary breast carcinoma are frequently infiltrated by dendritic cells (DC). The mechanisms involved in the localization and status of activation of DC within primary breast carcinoma were investigated. CCL20/MIP3alpha, a chemokine involved in immature DC and their precursors attraction, was detected by immunohistochemistry on cryopreserved tissue sections of primary breast tumors and by ELISA and biological...
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