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Article

Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-β.

Blood - 9 Oct 2014

Martínez-Cingolani Carolina, Grandclaudon Maximilien, Jeanmougin Marine, Jouve Mabel, Zollinger Raphaël, Soumelis Vassili

Abstract excerpt

The ontogeny of human Langerhans cells (LCs) remains poorly characterized, in particular the nature of LC precursors and the factors that may drive LC differentiation. Here we report that thymic stromal lymphopoietin (TSLP), a keratinocyte-derived cytokine involved in epithelial inflammation, cooperates with transforming growth factor (TGF)-β for the generation of LCs. We show that primary human blood BDCA-1(+),...

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Source

Identifiers

PMID: 25114264
DOI: 10.1182/blood-2014-04-568311

Genes

TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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