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Article

Langerhans-cell histiocytosis 'insight into DC biology'.

Trends in immunology - 1 Apr 2003

Laman Jon D, Leenen Pieter J M, Annels Nicola E, Hogendoorn Pancras C W, Egeler R Maarten

Abstract excerpt

Langerhans-cell histiocytosis (LCH) is caused by an uncontrolled pathogenic clonal proliferation of dendritic cells (DCs) with Langerhans-cell (LC) characteristics. LCH cells are arrested in an immature, partially activated stage and show a deviant regulation of cell division. Their aberrant interactions with T cells and the lesional microenvironment are typified by high level production of diverse cytokines....

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PMID: 12697451
DOI: 10.1016/s1471-4906(03)00063-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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