Article
Mature human Langerhans cells derived from CD34+ hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2004
Ratzinger Gudrun, Baggers Jan, de Cos Maria A, Yuan Jianda, Dao Tao, Reagan John L, Münz Christian, Heller Glenn, Young James W
Abstract excerpt
The emerging heterogeneity of dendritic cells (DCs) mirrors their increasingly recognized division of labor at myriad control points in innate and acquired cellular immunity. We separately generated blood monocyte-derived DCs (moDCs), as well as Langerhans cells (LCs) and dermal-interstitial DCs (DDC-IDCs) from CD34(+) hematopoietic progenitor cells. Differential expression of CD11b, CD52, CD91, and the CD1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.