Article
CD34+ -derived Langerhans cell-like cells are different from epidermal Langerhans cells in their response to thymic stromal lymphopoietin.
Journal of cellular and molecular medicine - 1 Sept 2011
Nguyen Van Anh, Dubrac Sandrine, Forstner Markus, Huter Otto, Del Frari Barbara, Romani Nikolaus, Ebner Susanne
Abstract excerpt
Thymic stromal lymphopoietin (TSLP) endows human blood-derived CD11c(+) dendritic cells (DCs) and Langerhans cells (LCs) obtained from human epidermis with the capacity to induce pro-allergic T cells. In this study, we investigated the effect of TSLP on umbilical cord blood CD34(+) -derived LC-like cells. These cells are often used as model cells for LCs obtained from epidermis. Under the influence of TSLP, both...
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