Article
A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2004
Lasota Jerzy, Dansonka-Mieszkowska Agnieszka, Sobin Leslie H, Miettinen Markku
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are KIT expressing spindle cell, epithelioid and rarely pleomorphic mesenchymal tumors. The majority of GISTs show gain-of-function KIT mutations. However, GISTs without KIT mutations and GISTs with weak or lack of immunohistochemical KIT expression have also been reported. Recently, gain-of-function mutations in exon 18 (activation loop) and exon 12 (juxtamembrane domain)...
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