Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Platelet-derived growth factor receptor family mutations in gastrointestinal stromal tumours.

Scandinavian journal of gastroenterology - 1 Jul 2006

Sihto Harri, Franssila Kaarle, Tanner Minna, Vasama-Nolvi Carita, Sarlomo-Rikala Maarit, Nupponen Nina N, Joensuu Heikki, Isola Jorma

Abstract excerpt

OBJECTIVE: Activating mutations of either KIT or platelet-derived growth factor receptor alpha (PDGFRA) genes are present in the majority of gastrointestinal stromal tumours (GISTs). The type of gene mutation is associated with the aggressiveness of the disease, response to imatinib therapy, and the tumour site in the gastrointestinal tract. However, a subgroup of GISTs does not harbour these mutations. MATERIAL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Intestinal Neoplasms

Share to Peritoneal Neoplasms

Share to Proto-Oncogene Proteins c-kit

Share to Receptors, Platelet-Derived Growth Factor

Share to Stomach Neoplasms

Source

Identifiers

PMID: 16785193
DOI: 10.1080/00365520500483207

Genes

KIT
PDGFRA
FLT3
PDGFRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Platelet-derived growth factor receptor family mutations in gastrointestinal stromal tumours.PMID 16785193Read ↗

PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.Semantic proximity Read ↗

Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours.Semantic proximity Read ↗

KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs).Semantic proximity Read ↗

KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors.Semantic proximity Read ↗

KIT and PDGFRA mutations and PDGFRA immunostaining in gastrointestinal stromal tumors.Semantic proximity Read ↗

A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential.Semantic proximity Read ↗

Pathological characteristics of gastrointestinal stromal tumours with PDGFRA mutations.Semantic proximity Read ↗

Tyrosine-kinase mutations in c-KIT and PDGFR-alpha genes of imatinib naïve adult patients with gastrointestinal stromal tumours (GISTs) of the stomach and small intestine: relation to tumour-biological risk-profile and long-term outcome.Semantic proximity Read ↗

Clinical implications of KIT and PDGFRA genotyping in GIST.Semantic proximity Read ↗

PDGFRA Immunohistochemistry Predicts PDGFRA Mutations in Gastrointestinal Stromal Tumors.Semantic proximity Read ↗

Biology of gastrointestinal stromal tumors.Semantic proximity Read ↗

Analysis of mutation of the c-Kit gene and PDGFRA in gastrointestinal stromal tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.