Article
[Gastrointestinal stromal tumors carrying PDGFRalpha mutations occur preferentially in the stomach and exhibit an epithelioid or mixed phenotype].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 2004
Wardelmann E, Pauls K, Merkelbach-Bruse S, Hrychyk A, Losen I, Hohenberger P, Büttner R, Pietsch T
Abstract excerpt
AIMS: Most gastrointestinal stromal tumors (GISTs) carry gain-of-function mutations of the KIT gene encoding the receptor tyrosine kinase KIT. However, in a subset of GISTs no activating mutations are detectable in KIT. Recently, PDGFRalpha mutations have been identified as alternative oncogenic mechanism. We studied a panel of 100 GISTs for mutations in hot spot regions of KIT (exons 9, 11, 13 and 17) and...
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