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Article

PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2005

Corless Christopher L, Schroeder Arin, Griffith Diana, Town Ajia, McGreevey Laura, Harrell Patina, Shiraga Sharon, Bainbridge Troy, Morich Jason, Heinrich Michael C

Abstract excerpt

PURPOSE: Gastrointestinal stromal tumors (GISTs) commonly harbor oncogenic mutations of the KIT tyrosine kinase, which is a target for the kinase inhibitor imatinib. A subset of GISTs, however, contains mutations in the homologous kinase platelet derived growth factor receptor alpha (PDGFRA), and...

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Source

Identifiers

PMID: 15928335
DOI: 10.1200/JCO.2005.14.068

Genes

PDGFRA
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15928335-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.PMID 15928335Read ↗

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