Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-cell-dependent immune responses, germinal center development, and the analysis of V-gene sequences.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004

Berek Claudia

Abstract excerpt

To determine whether an immune system is able to support T-cell-dependent affinity maturation one needs antigens that induce well-characterized immune responses. This chapter describes the response of the BALB/c mouse to hapten 2-phenyl-4-ethoxymethylene-oxazolone (phOx) coupled to carrier protein chicken serum albumin (CSA). Immunization with this hapten carrier complex will induce the formation of germinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oxazoles
Share to Serum Albumin
Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Germinal Center

Share to Immunization

Share to Microdissection

Share to T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 15146117
DOI: 10.1385/1-59259-796-3:127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-cell-dependent immune responses, germinal center development, and the analysis of V-gene sequences.PMID 15146117Read ↗

Low antigen dose favours selection of somatic mutants with hallmarks of antibody affinity maturation.Semantic proximity Read ↗

The effect of carrier and carrier priming on the kinetics and pattern of somatic mutation in the V chi Ox1 gene.Semantic proximity Read ↗

Structural basis of affinity maturation of the TEPC15/Vkappa45.1 anti-2-phenyl-5-oxazolone antibodies.Semantic proximity Read ↗

Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response.Semantic proximity Read ↗

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone.Semantic proximity Read ↗

Regulation of VH gene repertoire and somatic mutation in germinal centre B cells by passively administered antibody.Semantic proximity Read ↗

Why are there so few key mutant clones? The influence of stochastic selection and blocking on affinity maturation in the germinal center.Semantic proximity Read ↗

Thymus-independent type 2 antigen induces a long-term IgG-related network memory.Semantic proximity Read ↗

Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin.Semantic proximity Read ↗

Maturation of the antibody response to the major epitope on the self antigen mouse cytochrome c. Restricted V gene usage, selected mutations, and increased affinity.Semantic proximity Read ↗

Allelic differences in the VHOx-1 gene explain the absence of a B cell clonal dominance in the primary response of C57BL/6 mice to phthalate.Semantic proximity Read ↗

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.