T-cell-dependent immune responses, germinal center development, and the analysis of V-gene sequences.

doi:10.1385/1-59259-796-3:127

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Article

T-cell-dependent immune responses, germinal center development, and the analysis of V-gene sequences.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004

Berek Claudia

Abstract excerpt

To determine whether an immune system is able to support T-cell-dependent affinity maturation one needs antigens that induce well-characterized immune responses. This chapter describes the response of the BALB/c mouse to hapten 2-phenyl-4-ethoxymethylene-oxazolone (phOx) coupled to carrier protein chicken serum albumin (CSA). Immunization with this hapten carrier complex will induce the formation of germinal...

Topics

Animals
B-Lymphocytes
Chickens
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Germinal Center
Immunization
Mice
Mice, Inbred BALB C
Microdissection
Mutation
Oxazoles
Sequence Analysis
Serum Albumin
Spleen
T-Lymphocytes, Helper-Inducer

Source

Open in PubMed

Identifiers

PMID: 15146117
DOI: 10.1385/1-59259-796-3:127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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