Article
Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process.
Journal of neuroimmunology - 1 Jun 2004
Mix Eilhard, Ibrahim Saleh, Pahnke Jens, Koczan Dirk, Sina Christian, Böttcher Tobias, Thiesen Hans-Jürgen, Rolfs Arndt
Abstract excerpt
Experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) is a well-established animal model of multiple sclerosis (MS) in rodents. It reflects the wide spectrum of disease pathology and serves as a valuable tool for studying the pathogenesis and for testing new therapies of MS. In order to identify genes responsible for resistance to and modulation of the disease, we...
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