Article
Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis.
Annals of neurology - 1 Dec 2011
Blankenhorn Elizabeth P, Butterfield Russell, Case Laure K, Wall Emma H, del Rio Roxana, Diehl Sean A, Krementsov Dimitry N, Saligrama Naresha, Teuscher Cory
Abstract excerpt
OBJECTIVE: The major histocompatibility complex (MHC) is the primary genetic contributor to multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), but multiple additional interacting loci are required for genetic susceptibility. The identity of most of these non-MHC genes is unknown. In this report, we identify genes within evolutionarily conserved genetic pathways leading to MS and EAE....
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