Article
Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2003
Karlsson Jenny, Zhao Xiangshan, Lonskaya Irina, Neptin Malin, Holmdahl Rikard, Andersson Asa
Abstract excerpt
The B10.RIII mouse strain (H-2(r)) develops chronic experimental autoimmune encephalomyelitis (EAE) upon immunization with the myelin basic protein 89-101 peptide. EAE was induced and studied in a backcross between B10.RIII and the EAE-resistant RIIIS/J strain (H-2(r)), and a complete genome scan with microsatellite markers was performed. Five loci were significantly linked to different traits and clinical...
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