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Article

Exploiting genotypic differences to identify genes important for EAE development.

Journal of the neurological sciences - 15 Dec 2005

Jelinsky Scott A, Miyashiro Joy S, Saraf Kathryn A, Tunkey Christopher, Reddy Padma, Newcombe Jia, Oestreicher Judith L, Brown Eugene, Trepicchio William L, Leonard John P, Marusic Suzana

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) is an animal model of the human autoimmune disease multiple sclerosis (MS) and is primarily driven by T helper type 1 (Th1) cells. Interleukin (IL)-12 and interferon (IFN)-gamma are important cytokines involved in the differentiation and amplification of Th1 cells, however mice deficient in either IFN-gamma or IL-12 still develop EAE. We have used microarray...

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Source

Identifiers

PMID: 16214174
DOI: 10.1016/j.jns.2005.08.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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