Article
Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission.
BMC medical genetics - 19 Mar 2008
Arthur Ariel T, Armati Patricia J, Bye Chris, Heard Robert N S, Stewart Graeme J, Pollard John D, Booth David R
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Although the pathogenesis of MS remains unknown, it is widely regarded as an autoimmune disease mediated by T-lymphocytes directed against myelin proteins and/or other oligodendrocyte epitopes. METHODS: In this study we investigated the gene expression profiles of peripheral blood cells from patients...
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