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Article

Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2010

deLuca Leslie E Summers, Pikor Natalia B, O'Leary Jennifer, Galicia-Rosas Georgina, Ward Lesley A, Defreitas Dustin, Finlay Trisha M, Ousman Shalina S, Osborne Lucy R, Gommerman Jennifer L

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) is a rodent model of multiple sclerosis that is executed in animals by immunization with myelin Ag in adjuvant. The SJL/J autoimmune-prone strain of mouse has been used to model relapsing-remitting multiple sclerosis. However, significant variations in peak scores, timing of onset, and incidence are observed among laboratories, with the postacute (relapse) phase of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Mice, Inbred Strains

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Identifiers

PMID: 20173032
DOI: 10.4049/jimmunol.0902881
PMCID: PMC3160975

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