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Article

The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.

Molecular cell - 7 May 2015

Stijf-Bultsma Yvette, Sommer Lilly, Tauber Maria, Baalbaki Mai, Giardoglou Panagiota, Jones David R, Gelato Kathy A, van Pelt Jason, Shah Zahid, Rahnamoun Homa, Toma Clara, Anderson Karen E, Hawkins Philip, Lauberth Shannon M, Haramis Anna-Pavlina G, Hart Daniel, Fischle Wolfgang, Divecha Nullin

Abstract excerpt

Phosphoinositides (PI) are important signaling molecules in the nucleus that influence gene expression. However, if and how nuclear PI directly affects the transcriptional machinery is not known. We report that the lipid kinase PIP4K2B regulates nuclear PI5P and the expression of myogenic genes during myoblast differentiation. A targeted screen for PI interactors identified the PHD finger of TAF3, a TATA box...

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Identifiers

PMID: 25866244
DOI: 10.1016/j.molcel.2015.03.009
PMCID: PMC4429956

Genes

TAF3

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