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Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertility

6 May 2023

Abstract excerpt

Abstract Genetic studies elucidate a link between testis-specific serine/threonine kinases (TSSKs) and male infertility in mammals, but the underlying mechanisms are unclear. Here, we identify a TSSK homolog inDrosophila, CG14305 (termed dTSSK), whose mutation impairs the histone-to-protamine transition during spermiogenesis and causes multiple phenotypic defects in nuclear shaping, DNA condensation, and...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 37149634
DOI: 10.1038/s41467-023-38357-0

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