Article

Phosphorylation of the ancestral histone variant H3.3 amplifies stimulation-induced transcription

2019-10-17

Abstract excerpt

Complex organisms are able to rapidly induce select genes among thousands in response to diverse environmental cues. This occurs in the context of large genomes condensed with histone proteins into chromatin. The macrophage response to pathogen sensing, for example, rapidly engages highly conserved signaling pathways and transcription factors (TFs) for coordination of inflammatory gene induction 1–3 . Enriched in...

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Literature Corpus work: ca49bae5-8585-5f5c-a64d-eb644ac905dc
DOI: 10.1101/808048

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