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Article

dUTP incorporation into genomic DNA is linked to transcription in yeast.

Nature - 25 Jun 2009

Kim Nayun, Jinks-Robertson Sue

Abstract excerpt

Highly activated transcription is associated with eukaryotic genome instability, resulting in increased rates of mitotic recombination and mutagenesis. The association between high transcription and genome stability is probably due to a variety of factors including an enhanced accumulation of DNA damage, transcription-associated supercoiling, collision between replication forks and the transcription machinery,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19448611
DOI: 10.1038/nature08033
PMCID: PMC2730915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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dUTP incorporation into genomic DNA is linked to transcription in yeast.PMID 19448611Read ↗

The connection between transcription and genomic instability.Semantic proximity Read ↗

Ribonucleotides and Transcription-Associated Mutagenesis in Yeast.Semantic proximity Read ↗

Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled nucleotide excision repair.Semantic proximity Read ↗

Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA.Semantic proximity Read ↗

Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication.Semantic proximity Read ↗

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast.Semantic proximity Read ↗

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase.Semantic proximity Read ↗

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast DNA polymerase epsilon participates in leading-strand DNA replication.Semantic proximity Read ↗

Targeted detection of in vivo endogenous DNA base damage reveals preferential base excision repair in the transcribed strand.Semantic proximity Read ↗

The mutagenic potential of a single DNA double-strand break in a mammalian chromosome is not influenced by transcription.Semantic proximity Read ↗

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