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Article

Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening.

The Journal of pathology - 1 Jun 2004

Carneiro Fátima, Huntsman David G, Smyrk Thomas C, Owen David A, Seruca Raquel, Pharoah Paul, Caldas Carlos, Sobrinho-Simões Manuel

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome caused, in 30-40% of cases, by germline mutations of the E-cadherin/CDH1 gene. The presence of clinically undetectable early gastric cancers has been previously reported in ten of ten prophylactic gastrectomies from germline E-cadherin mutation carriers. In the present study, detailed maps of the distribution of invasive cancers in nine of...

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Identifiers

PMID: 15141383
DOI: 10.1002/path.1564

Genes

CDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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