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Article

Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening.

The Journal of pathology - 1 Jun 2004

Carneiro Fátima, Huntsman David G, Smyrk Thomas C, Owen David A, Seruca Raquel, Pharoah Paul, Caldas Carlos, Sobrinho-Simões Manuel

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome caused, in 30-40% of cases, by germline mutations of the E-cadherin/CDH1 gene. The presence of clinically undetectable early gastric cancers has been previously reported in ten of ten prophylactic gastrectomies from germline E-cadherin mutation carriers. In the present study, detailed maps of the distribution of invasive cancers in nine of...

Topics

Adult
Biopsy
Cadherins
Carcinoma in Situ
Carcinoma, Signet Ring Cell
Family Health
Female
Gastric Mucosa
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Mutation

Neoplasm Invasiveness

Precancerous Conditions

Stomach Neoplasms

Source

Identifiers

PMID: 15141383
DOI: 10.1002/path.1564

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15141383-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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