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Article

Characterization of Tollip protein upon Lipopolysaccharide challenge.

Molecular immunology - 1 May 2004

Li Tao, Hu Jean, Li Liwu

Abstract excerpt

Tollip protein serves as a suppressor of innate immunity signaling with unknown mechanism. In this report, we observed that Tollip preferentially bound with phosphatidylinositol-3-phosphate (PtdIns(3)P) and phosphatidylinositol-3,4,5-phosphate (PtdIns(3,4,5)P) in vitro. Mutation of lysine 150 to glutamic acid (Tollip(KE)) within the C2 domain abolished such binding, indicating that C2 domain is critically...

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Identifiers

PMID: 15140579
DOI: 10.1016/j.molimm.2004.03.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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