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Article

Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets.

Molecular and cellular biology - 1 Apr 2003

Ronni Tapani, Agarwal Vishal, Haykinson Michael, Haberland Margaret E, Cheng Genhong, Smale Stephen T

Abstract excerpt

Toll-like receptor 4 (TLR4) mediates the host response to lipopolysaccharide (LPS) by promoting the activation of pro- and anti-inflammatory cytokine genes. To activate each gene, numerous signal transduction pathways are required. The adaptor proteins MyD88 and TIRAP contribute to the activation of several and possibly all pathways via direct interactions with TLR4's Toll/interleukin-1 receptor (IL-1R) (TIR)...

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Source

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Identifiers

PMID: 12640135
DOI: 10.1128/MCB.23.7.2543-2555.2003
PMCID: PMC150739

Genes

TLR4
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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