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Article

The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides.

The Biochemical journal - 1 May 2011

Ankem Gayatri, Mitra Sharmistha, Sun Furong, Moreno Anna C, Chutvirasakul Boonta, Azurmendi Hugo F, Li Liwu, Capelluto Daniel G S

Abstract excerpt

TLRs (Toll-like receptors) provide a mechanism for host defence immune responses. Activated TLRs lead to the recruitment of adaptor proteins to their cytosolic tails, which in turn promote the activation of IRAKs (interleukin-1 receptor-associated kinases). IRAKs act upon their transcription factor targets to influence the expression of genes involved in the immune response. Tollip (Toll-interacting protein)...

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Identifiers

PMID: 21294713
DOI: 10.1042/BJ20102160

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