Article
X-linked inhibitor of apoptosis protein controls alpha5-integrin-mediated cell adhesion and migration.
American journal of physiology. Heart and circulatory physiology - 1 Aug 2010
Kim Jongmin, Ahn Sunyoung, Ko Young-Gyu, Boo Yong Chool, Chi Sung-Gil, Ni Chih-Wen, Go Young-Mi, Jo Hanjoong, Park Heonyong
Abstract excerpt
The association of integrins with caveolin-1 regulates cell adhesion. However, the vascular ramifications of this association remain to be clearly determined. We recently reported that the X chromosome-linked inhibitor of apoptosis protein (XIAP)-caveolin-1 interaction is critical to endothelial cell survival. Thus, we hypothesized that XIAP performs a crucial function in integrin/caveolin-1-mediated endothelial...
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