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Article

Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway.

Biochemical and biophysical research communications - 12 Dec 2014

Yoshimoto Taisuke, Takino Takahisa, Li Zichen, Domoto Takahiro, Sato Hiroshi

Abstract excerpt

Vinculin regulates a variety of cellular functions partly through stabilization of tumor suppressor PTEN. In order to study the role of vinculin in tumor progression other than PTEN stabilization, vinculin was knocked down in PTEN-deficient squamous cell carcinoma HSC-4 cells. Knockdown of vincul...

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Source

Identifiers

PMID: 25449281
DOI: 10.1016/j.bbrc.2014.10.154

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25449281-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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