Article
Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins.
Molecular and cellular biology - 1 Oct 2000
Liu B P, Burridge K
Abstract excerpt
The Rho family of GTPases plays a major role in the organization of the actin cytoskeleton. These G proteins are activated by guanine nucleotide exchange factors that stimulate the exchange of bound GDP for GTP. In their GTP-bound state, these G proteins interact with downstream effectors. Vav2 is an exchange factor for Rho family GTPases. It is a ubiquitously expressed homologue of Vav1, and like Vav1, it has...
Topics
- 3T3 Cells
- Actin Cytoskeleton
- Actins
- Amino Acid Substitution
- Animals
- Cell Membrane
- Cells, Cultured
- Cytoskeleton
- Epidermal Growth Factor
- Extracellular Matrix
- Fibroblasts
- Guanosine Diphosphate
- Guanosine Triphosphate
- Humans