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Article

Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer.

Cancer biology & therapy - 1 Jul 2013

Kawada Ichiro, Hasina Rifat, Lennon Frances E, Bindokas Vytautas P, Usatyuk Peter, Tan Yi-Hung C, Krishnaswamy Soundararajan, Arif Qudsia, Carey George, Hseu Robyn D, Robinson Matthew, Tretiakova Maria, Brand Toni M, Iida Mari, Ferguson Mark K, Wheeler Deric L, Husain Aliya N, Natarajan Viswanathan, Vokes Everett E, Singleton Patrick A, Salgia Ravi

Abstract excerpt

Cytoskeletal and focal adhesion abnormalities are observed in several types of cancer, including lung cancer. We have previously reported that paxillin (PXN) was mutated, amplified, and overexpressed in a significant number of lung cancer patient samples, that PXN protein was upregulated in more advanced stages of lung cancer compared with lower stages, and that the PXN gene was also amplified in some...

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Identifiers

PMID: 23792636
DOI: 10.4161/cbt.25091
PMCID: PMC3742497

Genes

PXN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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