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Article

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.

The Journal of biological chemistry - 31 Dec 2004

Barthelmes Hans U, Habermeyer Michael, Christensen Morten O, Mielke Christian, Interthal Heidrun, Pouliot Jeffrey J, Boege Fritz, Marko Doris

Abstract excerpt

Tyrosyl DNA phosphodiesterase 1 (TDP1) is a repair enzyme that removes adducts, e.g. of topoisomerase I from the 3'-phosphate of DNA breaks. When expressed in human cells as biofluorescent chimera, TDP1 appeared more mobile than topoisomerase I, less accumulated in nucleoli, and not chromosome-bound at early mitosis. Upon exposure to camptothecin both proteins were cleared from nucleoli and rendered less mobile...

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Source

Identifiers

PMID: 15494395
DOI: 10.1074/jbc.M405042200

Genes

TDP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.PMID 15494395Read ↗

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TDP1 splice-site mutation causes HAP1 cell hypersensitivity to topoisomerase I inhibition.Semantic proximity Read ↗

Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.Semantic proximity Read ↗

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapySemantic proximity Read ↗

TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcriptionSemantic proximity Read ↗

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1Semantic proximity Read ↗

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