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Article

Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison.

Journal of molecular biology - 28 Sept 2007

He Xiaoping, van Waardenburg Robert C A M, Babaoglu Kerim, Price Allen C, Nitiss Karin C, Nitiss John L, Bjornsti Mary-Ann, White Stephen W

Abstract excerpt

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) catalyzes the resolution of 3' and 5' phospho-DNA adducts. A defective mutant, associated with the recessive neurodegenerative disease SCAN1, accumulates Tdp1-DNA complexes in vitro. To assess the conservation of enzyme architecture, a 2.0 A crystal structure of yeast Tdp1 was determined that is very similar to human Tdp1. Poorly conserved regions of primary structure are...

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Identifiers

PMID: 17707402
DOI: 10.1016/j.jmb.2007.07.055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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