Article
Identification of tyrosyl-DNA phosphodiesterase as a novel DNA damage repair enzyme in Arabidopsis.
Plant physiology - 1 Nov 2010
Lee So-Young, Kim Hoyeun, Hwang Hyun-Ju, Jeong Young-Min, Na Sang Hyeon, Woo Je-Chang, Kim Sang-Gu
Abstract excerpt
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a key enzyme that hydrolyzes the phosphodiester bond between tyrosine of topoisomerase and 3'-phosphate of DNA and repairs topoisomerase-mediated DNA damage during chromosome metabolism. However, functional Tdp1 has only been described in yeast and human...
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