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Article

Null phenotype for cytochrome P450 2B2 in the rat results from a deletion of its structural gene.

Molecular pharmacology - 1 Aug 1992

Omiecinski C J, Ramsden R, Rampersaud A, Walz F G

Abstract excerpt

The absence of phenobarbital (PB)-inducible cytochrome P450 2B2 (CYP2B2) in hepatic microsomes from Marshall 520 (M520) and Wistar Munich (WM) inbred strains of rat was previously reported [Biochem. Genet. 25:527-534 (1987)], and it was subsequently shown for M520 rats that corresponding CYP2B2 mRNA was not detected in hepatic extracts from either control or PB-treated animals [DNA 8:29-37 (1989)]. In the present...

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PMID: 1513322

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