Article
Sequence analyses of CYP2B genes and catalytic profiles for P450s in Qdj:Sprague-dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2.
The Journal of pharmacology and experimental therapeutics - 1 Dec 2000
Yamada H, Matsunaga H, Tsuji K, Matsumoto S, Yamamoto M, Ishii Y, Omiecinski C J, Oguri K
Abstract excerpt
The Qdj:Sprague-Dawley (SD) rat is a mutant strain lacking in phenobarbital (PB)-mediated induction of CYP2B2. The presence of interindividual differences in the hepatic content of CYP2B proteins and testosterone 16beta-hydroxylase activity demonstrated that the breeding colony of Qdj:SD rats involves normal (+/+) and intermediate (+/-) phenotypes as well as mutant (-/-)-type rats. Although PB-treated Qdj:SD...
Topics
- Animals
- Aryl Hydrocarbon Hydroxylases
- Base Sequence
- Catalysis
- Cytochrome P-450 CYP2B1
- Cytochrome P-450 Enzyme System
- Enzyme Induction
- Male
- Phenobarbital
- Phenotype