Identification and functional characterization of a cis-acting positive DNA element regulating CYP 2B1/B2 gene transcription in rat liver.

doi:10.1093/nar/20.3.557

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Article

Identification and functional characterization of a cis-acting positive DNA element regulating CYP 2B1/B2 gene transcription in rat liver.

Nucleic acids research - 11 Feb 1992

Upadhya P, Rao M V, Venkateswar V, Rangarajan P N, Padmanaban G

Abstract excerpt

A positive cis-acting DNA element in the near 5'-upstream region of the CYP2B1/B2 genes in rat liver was found to play an important role in the transcription of these genes. An oligonucleotide covering -69 to -98 nt mimicked the gel mobility shift pattern given by the fragment -179 to +29 nt, whi...

Topics

Amanitins
Animals
Base Sequence
Cytochrome P-450 Enzyme System
Gene Expression Regulation
Male
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Phenobarbital
Rats
Regulatory Sequences, Nucleic Acid
Transcription, Genetic

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Identifiers

PMID: 1741290
DOI: 10.1093/nar/20.3.557
PMCID: PMC310423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1741290-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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