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Article

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice.

The Biochemical journal - 15 Jun 2005

Wang Xiu Jun, Chamberlain Mark, Vassieva Olga, Henderson Colin J, Wolf C Roland

Abstract excerpt

Cytochrome P450 reductase is the unique electron donor for microsomal cytochrome P450s; these enzymes play a major role in the metabolism of endogenous and xenobiotic compounds. In mice with a liver-specific deletion of cytochrome P450 reductase, hepatic cytochrome P450 activity is ablated, with consequent changes in bile acid and lipid homoeostasis. In order to gain insights into the metabolic changes resulting...

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Identifiers

PMID: 15717863
DOI: 10.1042/BJ20042087
PMCID: PMC1183466

Genes

POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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