Molecular basis for a functionally unique cytochrome P450IIB1 variant.

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Article

Molecular basis for a functionally unique cytochrome P450IIB1 variant.

The Journal of biological chemistry - 25 Nov 1991

Kedzie K M, Balfour C A, Escobar G Y, Grimm S W, He Y A, Pepperl D J, Regan J W, Stevens J C, Halpert J R

Abstract excerpt

Liver microsomes from phenobarbital-treated rats of four inbred strains expressing distinct allelic variants of cytochrome P450IIB1 were analyzed. The Wistar Munich (WM) strain exhibited 5- to 10-fold lower androstenedione 16 beta-hydroxylase activity (a specific P450IIB1 marker) than the Lewis,...

Topics

Alleles
Animals
Cloning, Molecular
Cytochrome P-450 CYP2B1
Cytochrome P-450 Enzyme System
DNA
Genetic Variation
Kinetics
Liver
Male
Microsomes, Liver
Oxidoreductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenobarbital

Plasmids

RNA

Rats

Rats, Inbred Lew

Rats, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 1718996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1718996-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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