Article
Cytochrome P450 2B enzyme (CYP2B) induction defect following phenobarbital treatment in the fa/fa Zucker rat: molecular characterization.
Archives of biochemistry and biophysics - 1 Jun 1993
Blouin R A, Bandyopadhyay A M, Chaudhary I, Robertson L W, Gemzik B, Parkinson A
Abstract excerpt
The present study describes the mechanism of the dampened induction of the CYP2B1 and CYP2B2 genes following phenobarbital treatment in the phenotypically obese fa/fa Zucker rat. The fa/fa Zucker rat demonstrated a threefold lower level of CYP2B1/2B2 enzyme induction, as indicated by reduced test...
Topics
- Animals
- Blotting, Northern
- Blotting, Western
- Cells, Cultured
- Cytochrome P-450 CYP2B1
- Cytochrome P-450 Enzyme System
- DNA Probes
- Liver
- Male
- Mutation
- Obesity
- Oxazines
- Oxidation-Reduction
- Oxidoreductases
- Phenobarbital
- RNA, Messenger
- Rats
- Rats, Zucker