Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation.

Genes & development - 1 May 2004

Grossi Simona, Puglisi Andrea, Dmitriev Petr V, Lopes Massimo, Shore David

Abstract excerpt

The regulation of telomerase action, and its coordination with conventional DNA replication and chromosome end "capping," are still poorly understood. Here we describe a genetic screen in yeast for mutants with relaxed telomere length regulation, and the identification of Pol12, the B subunit of the DNA polymerase alpha (Pol1)-primase complex, as a new factor involved in this process. Unlike many POL1 and POL12...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to DNA Polymerase I
Share to DNA Primase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Protein Subunits

Share to Saccharomyces cerevisiae Proteins

Share to Telomere

Share to Telomere-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 15132993
DOI: 10.1101/gad.300004
PMCID: PMC406290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation.PMID 15132993Read ↗

The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication.Semantic proximity Read ↗

TEN1 is essential for CDC13-mediated telomere capping.Semantic proximity Read ↗

Linear chromosome maintenance in the absence of essential telomere-capping proteins.Semantic proximity Read ↗

Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at TelomeresSemantic proximity Read ↗

A siRNA-based screen for genes involved in chromosome end protection.Semantic proximity Read ↗

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.Semantic proximity Read ↗

Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.Semantic proximity Read ↗

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.Semantic proximity Read ↗

A quantitative assay for telomere protection in Saccharomyces cerevisiae.Semantic proximity Read ↗

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1.Semantic proximity Read ↗

Survival and Growth of Yeast without Telomere Capping by Cdc13 in the Absence of Sgs1, Exo1, and Rad9Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.